ETV6/RUNX1 FUSION GENE ABROGATION DECREASES THE ONCOGENICITY OF TUMOUR CELLS IN A PRECLINICAL MODEL OF ACUTE LYMPHOBLASTIC LEUKAEMIA

ETV6/RUNX1 Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia

Background: The t(12;21)(p13;q22), which fuses ETV6 and RUNX1 genes, is the most common genetic abnormality a&d ej-123 in children with B-cell precursor acute lymphoblastic leukaemia.The implication of the fusion protein in leukemogenesis seems to be clear.However, its role in the maintenance of the disease continues to be controversial.Methods: Ge

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Spatial variability of the aspect sensitivity of VHF radar echoes in the troposphere and lower stratosphere during jet stream passages

The aspect sensitivity of SOUSY-VHF-radar oblique-beam echoes from the troposphere and lower stratosphere has been examined for a number of jet stream passages during the years 1990 princess jasmine silhouette - 1992.When the core of the jet is overhead or nearly so, vertical profiles of the aspect sensitivity display two notable features.First, th

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Myocardial Infarction and Depression

Background: Depressive symptoms are common among post myocardial infarction (MI) patients and may cause negative impacts on cardiac prognosis.35 to 45% of MI patients report depression.Depression is an independent risk factor for MI and post MI mortality and decreased quality of life in post MI patients.The link between depression and MI is bidirec

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